Impact of Asthma Phenotypes on Myocardial Performance and Pulmonary Hypertension in Children and Adolescents With Moderate to Severe Persistent Asthma

Background: Asthma is characterized by chronic inflammation and remodeling of pulmonary vessels airway wall resulting in hypertension (PH). Increased afterload on right ventricle (RV) myocardium leads to RV diastolic dysfunction (RVDD). Echocardiography an excellent tool detect these changes early. Using echocardiography, we assessed the impact clinical asthma phenotypes myocardial performance PH children with asthma. Materials methods: Sixty moderate or severe persistent 60 age gender-matched healthy controls were enrolled. As per phenotypes, classified into early wheezers (n = 30) late 30). Pulmonary function tests (PFT) both conventional pulse wave (PW), performed. Results: Children had significant RVDD higher incidence (33%) PH. Myocardial index (MPI) was poor asthmatics, 0.41 (0.04) compared controls, 0.38 (0.03). Measures for such as tricuspid regurgitation (TR) gradient, TR velocity, artery pressure (PAP) significantly cases. Among there no difference left ventricular ejection fraction (LVEF) between 64.3% (4.6) 65.6% (4.4). MPI better at (0.05) than 0.40 PAP wheezers. The odds ratio development 0.74 (CI 0.25 - 2.17), 3.2 0.77 13.8), favor Conclusion: asthma, particularly early-onset are increased risk developing RVDD. We suggest annual screening echocardiography Doppler imaging diagnosis timely initiation management.